our team of scientists
Throughout my medical studies, I noticed the difficulty of treating infertile couples with conventional treatments.
I was a researcher at the national institute of medical research (Inserm) and obstetrician gynecologist specializing in medical aid to procreation, I wanted to work on complementary solutions to treatments. This is how our team was able to be the first to explore the oxidation reduction of the DNA of infertile couples.
Following this research, we understood the paramount importance of making supplements for the protection of gamete DNA. We have therefore associated them with the treatments of our patients, and the results have been spectacular in many cases.
These formulas have been the subject of studies that have been published over the past ten years in numerous French and international publications.
Biologist Co-Manager of the CLEMENT laboratory, since November 1990.
Medical Assistance to Procreation.
Screening for trisomy 21.
Prenatal Diagnosis (Cytogenetics)
Molecular genetics in infertility.
Yves MENEZO got his Ph D thesis in 1971 from the University of Lyon (France) and then his Dr of Sciences in 1979. His work is devoted to the metabolism of the preimplantation embryo and the metabolic exchanges with the female genital tract. He has been first à researcher at INRA the French Public Institute for Agricultural Research. He designed in 1976 the first synthetic culture medium for reproductive biotechnologies in farm animals. He has been nominated as associated Professor in the department of animal sciences at the LSU, Louisiana State University in Baton Rouge. Then he left INRA in 1990 to follow Dr Charles Mérieux at the Mérieux Foundation as head of the ART Unity. He left in 2007 and is now an independent scientific adviser. His research is currently focused on epigenetic problems in reproduction and their possible impacts on future generations. Pr Menezo has published more than 250 scientific papers and book chapters and developed several patents and “know how”.
What led you to look for an alternative solution?
This is related to my medical training course that started at the National Medical Research Institute in which I did my PhD in medicine ; this is also due in particular thanks to the meeting of 2 French doctors who worked in the United States :one in alternative medicine, the other as a biochemist at the national institute of agricultural research, with whom I still pursue my research.
The techniques of the time were mainly focused on the organic causes of infertility and did not suspect the essential dimension of biochemistry in fertility disorders.
What did you discover?
We have identified the problem of oxidative stress, which creates an imbalance between cellular defense against the attack of oxygen free radicals, as being the cause of many failures: At that time, we already recognized the role played by oxidative stress in spermatozoid DNA fractures and in the disruption of the gamete nucleus and, in general, the oxidation of membranes.
We developed indices of fragmentation and kernel disruption, which allowed us to develop indices of fragmentation and decondensation, and then treatments based on antioxidants that are highly reducing of this phenomenon. We realized then that these were only the consequences of the radical aggression but that the heart of the matter was in the mutations of the enzymes (including MTHFR) that render the action of B vitamins, especially folic acid and its coenzymes, ineffective in their role of recycling homocysteine and stabilizing methylation, an essential element of the reproduction.
We have therefore developed the identification of mutations of MTHFR and the use in our formulas of folic acid, biologically active.
What do you recommend?
First of all do not hang around when you see after six months (and not 2 years!) that regular sexual intercourses do not lead to pregnancy. Do not say we have time! especially when you are 35 years old … remember that endocrine disruptors, group B nutritional or genetic deficiency, junk food, the environment, etc. are problematic!
It is therefore necessary to consult fertility specialists who must, in addition to standard examinations, explore oxidative stress and research enzymatic mutations for the man and the woman.