Help for infertile or subfertile couples

 

The healthy cell cycle at the heart of reproductive health and normal embryonic development

A healthy cell cycle is based on a series of biochemical events that allow the protection, proper functioning of the DNA and maintenance of its structural integrity. These biochemical pillars include, among others, duplication, methylation and DNA repair. Proper synchronization of these processes ensures rapid and unaffected cell division, which can be very important during periods of high cell proliferation such as embryonic development, gametogenesis or follicle growth.

Metabolically active folic acid: its importance for fertility and a healthy pregnancy

Folic acid (or folate or vitamin B9): properties known for a long time
The fundamental role of folic acid in the process of cell division has been known for many years. A low folate intake can cause cell cycle arrest, increase the rate of DNA breaks and cause a slowdown in DNA duplication or cell necrosis (ref 1). Folates are major players in DNA methylation, with methylation being a chemical modification (the transfer of a methyl group -CH3) as part of epigenetic regulation. Disruption of epigenetic regulation during gamete growth and early development may increase the risk of genomic imprint disorders and associated syndromes (Beckwith-Wiedemann, Angelman, Silver-Russell syndromes) of the child.

Classic folic acid is not operational without enzymatic modification

To bring all its benefits, folic acid must be reduced in the body by a set of folate cycle enzymes; the last transformation is carried out by the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR). With this modification, folic acid becomes metabolically active and usable by the body (image 1).

Enzymatic mutations involved in vitamin B9 deficiency: high associated risks

More than 70% of the population carries at least one mutation of the MTHFR gene; in some cases, an enzymatic deficiency appears which makes the process of transformation of the folic acid in its metabolically active form not very effective. This deficiency leads to a lack of operational vitamin B9 even though folic acid intake is important. As a result, the risk of folate deficiency in individuals with a MTHFR mutation is higher: male and female fertility disorders, miscarriage, development of neural tube defects in the developing fetus, heart disease congenital, cleft lip and palate, etc …

A contribution of metabolically active folic acid to cover the risks even in case of enzymatic mutations of the folate cycle

Being absolutely essential for normal fertility and reproduction, this vitamin must be associated with all pregnancy projects. The use of folic acid in its metabolically active form would cover the risks associated with its inadequate intake for all, including people carrying enzymatic mutations of the folate cycle.

Additional support for folate and methionine cycles to stabilize methylation and intensify homocysteine recycling.

Homocysteine is the result of chemical transformations of the methionine cycle

Homocysteine is a nonproteinogenic amino acid made in the methionine cycle when transferring methyl groups for methylation. Once made, homocysteine must either be changed to methionine to re-enter the methionine cycle or be recycled to produce cysteine. The catalytic activity of the enzymes responsible for this transformation requires vitamins B9, B12 or B6 as well as zinc. Insufficient intake of these elements or enzymatic deficiency can cause a high level of homocysteine (homocysteinemia).

Link with health risks and health

The level of homocysteine in the blood is positively correlated with cardiovascular risks as well as with the risks of miscarriage and congenital malformations. This amino acid is both an indicator of these risks and their cause. Indeed homocysteinemia reflects a dysfunction in the associated biochemical cycles (folate and methionine) that may be related to nutritional deficiency (vitamin B, zinc) or enzymatic.
The accumulation of homocysteine causes an imbalance in the methionine cycle, reducing the amount of the donor methyl groups, which affects the methylation and can lead to a state of general hypomethylation.
In addition, homocysteine itself is harmful: it combines with proteins by modifying their function, reduces the activity of glutathione peroxidase – one of the main defense enzymes against oxidative stress – and generates free radicals. The enzymatic system that provides stable methylation and DNA integrity for normal cell division is dependent on a sufficient supply of B-group vitamins and zinc. Supplementation with B vitamins and zinc therefore improves fertility and reduces the risk of fetal malformations.

Oxidative stress has a bad effect on the quality of gametes

Oxidative stress is a chemical attack of cellular macromolecules – DNA, fatty acids and proteins – by free radicals and peroxides. This modification disrupts the function of the cellular components and may cause DNA mutations. Natural defense mechanisms against oxidative stress include enzymes that neutralize free radicals by using molecules with strong reducing properties, glutathione being the main endogenous element of this defense.
Decreased effectiveness of the oxidative stress defense systems may be related to age and / or lifestyle with a significant negative impact on gamete quality and fertility. An intake of exogenous antioxidants helps protect cells by improving fertility. In addition, a contribution of cysteine, the amino acid to the glutathione synthesis base, and vitamin B6, essential for the recycling of homocysteine to cysteine, makes it possible to increase the synthesis of glutathione by reinforcing endogenous defense against oxidative stress.

 

What is Fertibiol ?
A food supplement for fertility, to reduce sperm DNA fractures caused by oxidative stress.
Fertibiol provides strong antioxidants to protect membranes and prevent DNA breaks.
A food supplement composed of plants, with amino acids, zinc, coenzyme Q10 and vitamins.

  • Zinc contributes to normal fertility and reproduction
  • Vitamins B6, B9 and B12 participate in the normal metabolism of homocysteine
  • Vitamin B6 helps the normal synthesis of cysteine

Composition
Prickly pear fruit powder (Opuntia ficus indica), N-acetyl-cysteine, zinc bisglycinate, L-tyrosine, L-carnitine-L-tartrate, olive fruit extract (Olea europae), fruit extract acerola (Malpighia glabra) titrated at 25% vitamin C, spore extract of Haematococcus (Haematococcus pluvialis), coenzyme Q10 (ubiquinone), green tea leaf extract (Camelia sinensis), folic acid (vitamin B9), hesperidin , D-alpha-tocopheryl succinate (vitamin E), beta-carotene (vitamin A), cyanocobalamin (vitamin B12), pyridoxine hydrochloride (vitamin B6), prickly pear seed powder, fish oil, microencapsulated rich in omega 3, D-alpha-tocopheryl acetate (vitamin E).

For who ?

  • For men who have fertility difficulties related to large numbers of DNA breaks in sperm, measured by the index of DNA fractures.
  • for all ages
  • To prepare procreation

Information
A one-month cure in case of extensive sperm DNA defragmentation (DFI> 25); must be followed by a course of 3 months of Condensyl.

 

What is Condensyl ?
A food supplement used for fertility, in case of decondensation, disruption of sperm DNA. Condensyl helps reduce the disorganization of sperm DNA. Food supplement based on prickly pears, cystine, B vitamins including B9 in the form of (6S) -5-methyltetrahydrofolic acid (calcium salt), vitamin E and zinc.

  • Vitamin B2 and Vitamin E help protect cells against oxidative stress.
  • Vitamins B6, B9 and B12 participate in the normal metabolism of homocysteine, vitamin B6 contributing to the normal synthesis of cysteine.
  • Zinc contributes to the normal synthesis of DNA.
  • Zinc supports normal fertility and reproduction.

Composition

Zinc Bisglycinate, L-Cystine, Prickly Pear Seed Powder (Opuntia Ficus Indica), Prickly Pear Fruit Powder (Opuntia Ficus Indica), D-alpha-Tocopheryl Acetate (Vitamin E), Nicotinamide (Vitamin B3) ), pyridoxine hydrochloride (vitamin B6), riboflavin (vitamin B2), (6S) -5-methyltetrahydrofolic acid in the form of calcium salt (vitamin B9), methylcobalamin (vitamin B12).

For who ?

  • For men who experience fertility problems, due to excessive oxidative stress that is reflected by DNA decondensation
  • For all ages
  • To prepare procreation

Informations

  • Desire for pregnancy: Food supplement to be taken after a treatment of Fertibiol, and this, during 3 months from the project of pregnancy, until obtaining a pregnancy.
  • Presence of a malfunction:
    – of the cycle of transformation of folic acid into its active form
    – of the homocysteine transformation cycle
    – of DNA synthesis.

 

What is Vigueural ?
A food supplement that helps to optimize male fertility by fighting the decline in sperm motility.
Vigueural ingredients provide elevated energy metabolism and help improve sperm motility.
Food supplement based on maca root, goji berry, turmeric root and marine magnesium.
• Magnesium helps reduce fatigue.
• Maca supports physical and intellectual performance.
• Maca helps maintain sexual performance.

Composition
Maca root extract, magnesium oxide, L-carnitine tartrate, L-ornitin alpha-ketoglutarate, soy lecithin, goji berry extract, L-glutamine, turmeric root extract 70% curcumin.

For who ?

  • for men with fertility problems due to decreased sperm motility
  • for all ages
  • in preparation for a pregnancy

Information
Food supplement to take from the project of pregnancy until a pregnancy.

 

What is Procrelia Femme ?
Ante-natal food supplement that helps preserve the quality of oocytes. The different ingredients help to reduce the harmful action of free radicals on the oocyte structure. Food supplement based on L-cystine, fruit and seeds of prickly pear, quercetin, vitamins of group B, vitamin E, zinc and fish oil.

  • Zinc helps fertility and normal reproduction
  • Zinc contributes to the normal synthesis of DNA.
  • Vitamin B2 and Vitamin E help protect cells against oxidative stress.
  • Vitamins B6, B9 and B12 help the normal metabolism of homocysteine, vitamin B6 contributing to the normal synthesis of cysteine..

Composition
L-cystine, zinc bisglycinate, vitamin E acetate, quercetin, prickly pear seed and fruit powder (Opuntia Ficus Indica), nicotinamide (vitamin B3), cyanocobalamin (vitamin B12), pyridoxine hydrochloride (vitamin B6) , riboflavin (vitamin B2), (6S) -5-methyltetrahydrofolic acid in the form of calcium salt (vitamin B9), fish oil.

For who ?

  • Suitable for women with fertility problems due to excessive oxidative stress and women who wish to increase the quality of their oocytes
  • In preparation for pregnancy

Indications
Desire for pregnancy: food supplement to be taken from the project of pregnancy until the third month of pregnancy.

 

What is postmenox ?
A food supplement that helps in case of hormone depletion after menopause. It contains appropriate ingredients to combat the various annoyances that affect the health and morale of women after their fifties, as well as during the period following the disappearance of periods: weight gain, irritability, insomnia, hot flashes and night sweats, but especially bone risk and vaginal dryness. Nutritional supplement with herbs, fish oil, zinc and vitamins.
• Sage helps menauposal comfort
• Lignans found in flaxseed have oetrogenic properties and are therefore likely to help menopausal health
• Vitamin B6 contributes to the regulation of normal hormonal activity

Composition

Flaxseed extract, oat extract, padine zinc extract, hops extract, fish oil, yam extract, sarsaparilla root extract, vitamin B9, vitamin E, vitamin B3, vitamin B5, vitamin B12, vitamin D3, vitamin B6, vitamin B2, sage extract, root extract of Cimicifuga.

For who ?

➢ Suitable for women for whom signs of menopause are evident
➢ After menopause (1 year without period)

Informations

➢ Not recommended for people with liver problems
➢ Use for women with a personal or family history of breast cancer is not recommended