After twelve years of research, Australian scientists from the Victor Chang Cardiac Research Institute have published a study in the New England Journal of Medicine demonstrating the important role of nicotinamide adenine dinucleotide (NAD) in the normal development of the embryo and the positive impact of vitamin B3 on the production of NAD. The combination of these two elements would thus make it possible to avoid miscarriages and disabilities of newborns.
These results are based on the study of several families affected by cases of recurrent miscarriages and congenital malformations. It has always been difficult to pinpoint a cause for these malformations, which are present in only 2% of births :they can be due to multiple factors, genetic or environmental. However, the study of the genes of these families made it possible to highlight certain genetic mutations that they had in common affecting their production of NAD. This has shown that NAD deficiency for the pregnant woman can lead to sudden miscarriage or embryo malformations.
NAD plays a crucial role in the development of the embryo.
After this phase of studying human genes, laboratory tests were conducted on mice bearing a similar genetic mutation: almost all of them lost their embryos during miscarriage or gave birth to young mice suffering from malformation . However, the administration of vitamin B3 to these mice has allowed the total cessation of these two phenomena. This has proven that vitamin B3 is an effective alternative to the usual synthetic NAD pathway and thus increases NAD production.
The introduction of vitamin B3 into the diet of pregnant women would significantly reduce the number of miscarriages and birth defects.